Search results for "Syngeneic Bone Marrow Transplantation"

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Murine model of interstitial cytomegalovirus pneumonia in syngeneic bone marrow transplantation: persistence of protective pulmonary CD8-T-cell infil…

2000

ABSTRACTInterstitial pneumonia (IP) is a severe organ manifestation of cytomegalovirus (CMV) disease in the immunocompromised host, in particular in recipients of bone marrow transplantation (BMT). Diagnostic criteria for the definition of CMV-IP include clinical evidence of pneumonia together with CMV detected in bronchoalveolar lavage or lung biopsy. We have used the model of syngeneic BMT and simultaneous infection of BALB/c mice with murine CMV for studying the pathogenesis of CMV-IP by controlled longitudinal analysis. A disseminated cytopathic infection of the lungs with fatal outcome was observed only when reconstituting CD8 T cells were depleted. Neither CD8 nor CD4 T cells mediated…

ImmunologyPneumonia ViralBiologyCD8-Positive T-LymphocytesLymphocyte ActivationMicrobiologyPathogenesisMiceVirologyImmunopathologymedicineCytotoxic T cellAnimalsHumansLungBone Marrow TransplantationMice Inbred BALB CLungmedicine.diagnostic_testSyngeneic Bone Marrow TransplantationDisease Models AnimalTransplantation Isogeneicmedicine.anatomical_structureBronchoalveolar lavagePhenotypeViral replicationInsect ScienceImmunologyCytomegalovirus InfectionsPathogenesis and ImmunityFemaleLung Diseases InterstitialCD8Journal of virology

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